Application
Western Blot at 1:1000 dilution + HACAT whole cell lysate Lysates/proteins at 20 ug per lane.| Product Name | TP63 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, p51, TP63, KET, P63, P73H, P73L, TP73L |
| Product description | This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.1) Du, Z., et al. Cancer Sci. 101(11):2417-2424(2010) |
| Immunogen | This TP63 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 651-680 amino acids from the C-terminal region of human TP63. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB starting dilution is: 1:1000: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TP63 |
|---|---|
| Alternative Names | Tumor protein 63 p63 Chronic ulcerative stomatitis protein CUSP Keratinocyte transcription factor KET Transformation-related protein 63 TP63 Tumor protein p73-like p73L p40 p51 TP63 KET P63 P73H P73L TP73L |
| Molecular Weight(MW) | 77 kDa |
Application
Western Blot at 1:1000 dilution + HACAT whole cell lysate Lysates/proteins at 20 ug per lane.| Application Notes | For WB starting dilution is: 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
