Application
Western blot analysis of TRESK in rat brain tissue lysate with TRESK antibody at (A) 1 and (B) 2 μg/mL.Application
Immunofluorescence of TRESK in Rat Brain cells with TRESK antibody at 20 μg/mL.Application
Immunohistochemistry of TRESK in rat brain tissue with TRESK antibody at 5 μg/mL.| Product Name | TRESK Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TRESK Antibody: TRIK, MGR13, TRESK, TRESK2, K2p18.1, TRESK-2, TRIK, Potassium channel subfamily K member 18, TWIK-related individual potassium channel |
| Product description | TRESK Antibody: TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.1) Sano Y, Inamura K, Miyake A, et al. A novel two-pore K+ channel, TRESK, is localized in the spinal cord. J. Biol. Chem.2003; 278:27406-12. |
| Immunogen | TRESK antibody was raised against a 17 amino acid synthetic peptide from near the center of human TRESK. The immunogen is located within amino acids 210 - 260 of TRESK. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| TRESK antibody can be used for detection of TRESK by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | KCNK18 |
|---|---|
| Alternative Names | TRESK Antibody: TRIK MGR13 TRESK TRESK2 K2p18.1 TRESK-2 TRIK Potassium channel subfamily K member 18 TWIK-related individual potassium channel |
Application
Western blot analysis of TRESK in rat brain tissue lysate with TRESK antibody at (A) 1 and (B) 2 μg/mL.
Application
Immunofluorescence of TRESK in Rat Brain cells with TRESK antibody at 20 μg/mL.
Application
Immunohistochemistry of TRESK in rat brain tissue with TRESK antibody at 5 μg/mL.| Positive Control | 1) Cat. No. 1463 - Rat Brain Tissue Lysate |
|---|---|
| Application Notes | TRESK antibody can be used for detection of TRESK by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | TRESK antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | TRESK Antibody is supplied in PBS containing 0.02% sodium azide. |
