This gene encodes a member of the tripartite motif (TRIM)
family, whose members are involved in diverse cellular functions
such as developmental patterning and oncogenesis. The TRIM motif
includes zinc-binding domains, a RING finger region, a B-box motif
and a coiled-coil domain. The RING finger and B-box domains chelate
zinc and might be involved in protein-protein and/or
protein-nucleic acid interactions. The gene mutations are
associated with mulibrey (muscle-liver-brain-eye) nanism, an
autosomal recessive disorder that involves several tissues of
mesodermal origin. Alternatively spliced transcript variants
encoding the same protein have been identified. [provided by
RefSeq].1) Xin, X., et al. Genome Res. 19(7):1262-1269(2009)
Immunogen
This TRIM37 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 936-964 amino acids from the C-terminal region of human TRIM37.
Western blot analysis in Hela cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.