This gene encodes one of the subunits of the tRNA splicing
endonuclease. This endonuclease catalyzes the first step in RNA
splicing which is the removal of introns. Mutations in this gene
have been associated with pontocerebellar hypoplasia type 2. A
pseudogene has been identified on chromosome 4. Multiple transcript
variants encoding different isoforms have been found for this gene.1) Weitzer, S., et al. Nature 447(7141):222-226(2007)
Immunogen
This TSEN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-43 amino acids from the N-terminal region of human TSEN2.
Western blot analysis in Hela cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.