Application
Immunohistochemistry of TTBK2 in human placenta tissue with TTBK2 antibody at 5 μg/mL.| Product Name | TTBK2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TTBK2 Antibody: TTBK, SCA11, KIAA0847, Tau-tubulin kinase 2 |
| Product description | TTBK2 Antibody: Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.1) Kitano-Takahashi M, Morita H, Kondo S, et al. Expression, purification and crystallization of a human tau-tubulin kinase 2 that phosphorylates tau protein. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2007; 63:602-4. |
| Immunogen | TTBK2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human TTBK2. The immunogen is located within the last 50 amino acids of TTBK2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| TTBK2 antibody can be used for detection of TTBK2 by immunohistochemistry at 5 μg/mL.: |
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| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TTBK2 |
|---|---|
| Alternative Names | TTBK2 Antibody: TTBK SCA11 KIAA0847 Tau-tubulin kinase 2 |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Mouse: (88%) |
| Tissue Specificity | TTBK2 antibody is human specific. At least four isoforms of TTBK2 are known to exist; this antibody will detect only the two largest isoforms. |
Application
Immunohistochemistry of TTBK2 in human placenta tissue with TTBK2 antibody at 5 μg/mL.| Application Notes | TTBK2 antibody can be used for detection of TTBK2 by immunohistochemistry at 5 μg/mL.: |
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| Form | Liquid |
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| Storage Instructions | TTBK2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | TTBK2 Antibody is supplied in PBS containing 0.02% sodium azide. |
