Application
Western Blot at 1:1000 dilution Lane 1: HT-1080 whole cell lysate Lane 2: U-251 MG whole cell lysate Lysates/proteins at 20 ug per lane.Application
Western blot analysis of ULBP2 using rabbit polyclonal ULBP2 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ULBP2 gene.| Product Name | ULBP2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NKG2D ligand 2, N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2, N2DL2, RAET1H |
| Product description | Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.1) McGilvray, R.W., et al. Int. J. Cancer 127(6):1412-1420(2010) |
| Immunogen | This ULBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-116 amino acids from the Central region of human ULBP2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB starting dilution is: 1:1000: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ULBP2 |
|---|---|
| Alternative Names | NKG2D ligand 2 N2DL-2 NKG2DL2 ALCAN-alpha Retinoic acid early transcript 1H UL16-binding protein 2 ULBP2 N2DL2 RAET1H |
| Molecular Weight(MW) | 27 kDa |
Application
Western Blot at 1:1000 dilution Lane 1: HT-1080 whole cell lysate Lane 2: U-251 MG whole cell lysate Lysates/proteins at 20 ug per lane.
Application
Western blot analysis of ULBP2 using rabbit polyclonal ULBP2 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ULBP2 gene.| Application Notes | For WB starting dilution is: 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
