This gene encodes a deubiquitinating enzyme that is
phosphorylated at the onset of mitosis and then dephosphorylated at
the metaphase/anaphase transition. It can deubiquitinate H2A, one
of two major ubiquitinated proteins of chromatin, in vitro and a
mutant form of the protein was shown to block cell division.
Alternate transcriptional splice variants, encoding different
isoforms, have been characterized.1) Gelsi-Boyer, V., et al. BMC Cancer 8, 299 (2008) :
Immunogen
This USP16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-160 amino acids from the N-terminal region of human USP16.
Western blot analysis in SK-BR-3 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.