Application
Immunohistochemistry staining of USP18 in heart tissue using USP18 Antibody.| Product Name | USP18 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | USP18, 43 kDa ISG15-specific protease, ISG43, HUBP43, ISG15 specific protease, Ubiquitin specific protease 18, Ubl thioesterase 18, Ubl thiolesterase 18, UBP43 |
| Product description | UBP43 (also known as ISG43, Ubl thiolesterase 18, ISG15-specific processing protease, 43 kDa ISG15-specific protease, ubiquitin specific protease 18 or USP18) is a member of the deubiquitinating protease family of enzymes, which removes ubiquitin adducts from a broad range of protein substrates. Deletion of the UBP43 gene in mouse leads to a massive increase of ISG15 conjugates in tissues indicating that UBP43 is a major ISG15-specific protease. UBP43 is the first ISG15-specific protease reported. Both ISG15 and UBP43 genes are known to be strongly induced by interferon, genotoxic stress, and viral infection. Thus UBP43 may be necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms. |
| Immunogen | USP18 antibody was raised against amino acids 40 - 49 of USP18 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHCWB |
| USP18 antibody can be used in ELISA starting at 1:10000 - 1:50000, Western Blot starting at 1:500 - 1:2000, immunohistochemistry starting at 5 μg/mL, and immunofluorescence.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | USP18 |
|---|---|
| Alternative Names | USP18 43 kDa ISG15-specific protease ISG43 HUBP43 ISG15 specific protease Ubiquitin specific protease 18 Ubl thioesterase 18 Ubl thiolesterase 18 UBP43 |
Application
Immunohistochemistry staining of USP18 in heart tissue using USP18 Antibody.| Application Notes | USP18 antibody can be used in ELISA starting at 1:10000 - 1:50000, Western Blot starting at 1:500 - 1:2000, immunohistochemistry starting at 5 μg/mL, and immunofluorescence.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store USP18 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide. |
