Application
Immunohistochemistry staining of VDAC1 in liver tissue using VDAC1 Antibody.| Product Name | VDAC1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | VDAC1, HVDAC1, Plasmalemmal porin, Porin 31HM, PORIN, PORIN-31-HL, Vdac5, VDAC, Mitochondrial porin, Porin 31HL, VDAC-1 |
| Product description | VDAC (also known as Voltage-dependent anion-selective channel protein 1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL) is an outer membrane mitochondrial protein. The VDAC proteins are ~30-33 kDa (some isoforms are larger - see below). The VDAC proteins are thought to form aqueous channels, or pores, through which adenine nucleotides cross the outer mito-chondrial membrane. VDACs have been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. This complex, formed by VDAC, adenine nucleotide translocator (ANT), and cyclophilin D (CypD), is thought to allow the mitochondria to undergo metabolic uncoupling and irreversible morphologic changes that ultimately destroy the mitochondria during apoptosis. VDACs are highly expressed in heart, liver and skeletal muscle, where concentrations of mitochondria are at their highest. This antibody can be used as a loading control with whole cell lysates and total mitochondrial preparations. |
| Immunogen | VDAC1 antibody was raised against amino acids 40 - 51 of VDAC1 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHCWB |
| VDAC1 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 1:500, immunofluorescence, and immunoprecipitation.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | VDAC1 |
|---|---|
| Alternative Names | VDAC1 HVDAC1 Plasmalemmal porin Porin 31HM PORIN PORIN-31-HL Vdac5 VDAC Mitochondrial porin Porin 31HL VDAC-1 |
Application
Immunohistochemistry staining of VDAC1 in liver tissue using VDAC1 Antibody.| Application Notes | VDAC1 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 1:500, immunofluorescence, and immunoprecipitation.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store VDAC1 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide. |
