Application
Western blot analysis of extracts from HT29 cells treated with Heatshock using Phospho-Vitamin D Receptor (Ser208) Antibody. The lane on the right is treated with the antigen-specific peptide.| Product Name | Vitamin D Receptor (phospho Ser208) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.1) Arriagada G, et al. (2007) J Steroid Biochem Mol Biol 103, 425-9. Jurutka PW, et al. (1996)Proc Natl Acad Sci U S A 93, 3519-24. Jurutka PW, et al. (1993)J Biol Chem 268, 6791-9. |
| Immunogen | Vitamin D Receptor (phospho Ser208) antibody was raised against a peptide sequence around phosphorylation site of serine 208 (A-L-S (p)-P-V) derived from Human Vitamin D Receptor. |
| Modification | p-Ser208 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western Blot: 1:500~1:1000 | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | VDR |
|---|---|
| Alternative Names | NR1I1 vitamin D receptor vitamin D3 receptor |
| Molecular Weight(MW) | 55 kDa |
| Tissue Specificity | The antibody detects endogenous level of Vitamin D Receptor only when phosphorylated at serine 208. |
| Entrez Gene | 7421 |
|---|---|
| Protein Accession | NP_000367.1 |
Application
Western blot analysis of extracts from HT29 cells treated with Heatshock using Phospho-Vitamin D Receptor (Ser208) Antibody. The lane on the right is treated with the antigen-specific peptide.| Application Notes | Western Blot: 1:500~1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
