Aminoacyl-tRNA synthetases catalyze the aminoacylation of
tRNA by their cognate amino acid. Because of their central role in
linking amino acids with nucleotide triplets contained in tRNAs,
aminoacyl-tRNA synthetases are thought to be among the first
proteins that appeared in evolution. Two forms of tryptophanyl-tRNA
synthetase exist, a cytoplasmic form, named WARS, and a
mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase
(WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan
and is induced by interferon. Tryptophanyl-tRNA synthetase belongs
to the class I tRNA synthetase family. Four transcript variants
encoding two different isoforms have been found for this gene.1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Immunogen
This WARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 429-458 amino acids from the C-terminal region of human WARS.
Western blot analysis in Jurkat cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.