Application
Western blot analysis of XKR8 in human stomach tissue lysate with XKR8 antibody at 1 μg/ml.Application
Immunofluorescence of XKR8 in human stomach tissue with XKR8 antibody at 20 μg/ml.Application
Immunohistochemistry of XKR8 in human stomach tissue with XKR8 antibody at 5 μg/ml.| Product Name | XKR8 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | XKR8 Antibody: XRG8, hXkr8, XRG8, XK-related protein 8 |
| Product description | The XK Kell blood group complex subunit-related family member 8 (XKR8) is a member of a family of proteins that promote the phagocytosis of dying cells by altering the phospholipid distribution of the plasma membrane (1). XKR8 is thought to be a “scramblase”, an enzyme that eliminates the asymmetry of phospholipid distribution in the plasma membrane. In apoptotic cells, XKR8 promotes the cell-surface exposure of phosphatidylserine (PtdSer) which serves as a signal for phagocytosis (1,2).1) Suzuki J, Denning DP, Imanishi E, et al. Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science 2013; 341:403-6. |
| Immunogen | XKR8 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human XKR8. The immunogen is located within the last 50 amino acids of XKR8. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| XKR8 antibody can be used for detection of XKR8 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | XKR8 |
|---|---|
| Alternative Names | XKR8 Antibody: XRG8 hXkr8 XRG8 XK-related protein 8 |
| Molecular Weight(MW) | Predicted: 43 kDa Observed: 47 kDa |
| Sequence Similarities | 2) Cat. No. 10-801 - Human Stomach Tissue Slide |
| Tissue Specificity | XKR8 antibody is human reactive. At least two isoforms are known to exist; this antibody will detect both isoforms. |
Application
Western blot analysis of XKR8 in human stomach tissue lysate with XKR8 antibody at 1 μg/ml.
Application
Immunofluorescence of XKR8 in human stomach tissue with XKR8 antibody at 20 μg/ml.
Application
Immunohistochemistry of XKR8 in human stomach tissue with XKR8 antibody at 5 μg/ml.| Positive Control | 1) Cat. No. 1319 - Human Stomach Tissue Lysate |
|---|---|
| Application Notes | XKR8 antibody can be used for detection of XKR8 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | XKR8 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| Storage Buffer | XKR8 antibody is supplied in PBS containing 0.02% sodium azide. |
