Application
Western blot analysis of ZC3H12B in mouse brain tissue lysate with ZC3H12B antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.Application
Immunohistochemistry of ZC3H12B in human brain tissue with ZC3H12B antibody at 5 μg/mL.| Product Name | ZC3H12B Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ZC3H12B Antibody: MCPIP2, CXorf32, MCPIP2, Probable ribonuclease ZC3H12B, MCP-induced protein 2 |
| Product description | ZC3H12B Antibody: ZC3H12B, also known as MCPIP2, is a member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation and may be involved in host immunity and inflammatory diseases. The function of ZC3H12B is not well understood. Unlike other members of the ZC3H12 family, ZC3H12B has a RasGEF domain at the C-terminal of the zinc finger motif, suggesting its potential involvement in Ras-mediated signal transduction. It is highly expressed in brain, thymus, and testis, but unlike ZC3H12A and ZC3H12C, not expressed in macrophages after treatment with lipopolysaccharide (LPS).1) Zhou L, Azfer A, Niu J, et al. Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction. Circ. Res.2006; 98:1177-85. |
| Immunogen | ZC3H12B antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human ZC3H12B. The immunogen is located within the first 50 amino acids of ZC3H12B. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHC-PWB |
| ZC3H12B antibody can be used for detection of ZC3H12B by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | ZC3H12B |
|---|---|
| Alternative Names | ZC3H12B Antibody: MCPIP2 CXorf32 MCPIP2 Probable ribonuclease ZC3H12B MCP-induced protein 2 |
| Sequence Similarities | 2) Cat. No. 10-301 - Human Brain Tissue Slide |
| Entrez Gene | 340554 |
|---|---|
| Protein Accession | NP_001010888 |
Application
Western blot analysis of ZC3H12B in mouse brain tissue lysate with ZC3H12B antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Application
Immunohistochemistry of ZC3H12B in human brain tissue with ZC3H12B antibody at 5 μg/mL.| Positive Control | 1) Cat. No. 1403 - Mouse Brain Tissue Lysate |
|---|---|
| Application Notes | ZC3H12B antibody can be used for detection of ZC3H12B by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | ZC3H12B antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | ZC3H12B Antibody is supplied in PBS containing 0.02% sodium azide. |
