Application
Fig1: Immunohistochemical analysis of paraffin-embedded rat skeletal muscle tissue using anti-Plectin antibody. Counter stained with hematoxylin.Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue using anti-Plectin antibody. Counter stained with hematoxylin.| Product Name | Plectin [SY29-04] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | EBS1 antibody EBSO antibody HD1 antibody Hemidesmosomal protein 1 antibody PCN antibody pleC antibody PLEC_HUMAN antibody PLEC1 antibody PLEC1b antibody Plectin 1 antibody Plectin 1 intermediate filament binding protein 500kDa antibody Plectin 6 antibody Plectin antibody Plectin-1 antibody PLTN antibody |
| Product description | Plectin is an abundant cytoskeletal protein that is involved in cytoplasm stabilization. Plectin has been shown to crosslink intermediate filaments to microtubules and microfilaments, and to anchor intermediate filaments to the plasma and nuclear membranes. Plectin binds both Lamin B and vimentin, and this binding is regulated by a variety of protein kinases. Phosphorylation by PKA or PKC results in decreased binding to Lamin B, and phosphorylation by PKA enhances the plectin-vimentin interactions. Plectin is also a substrate for p34cdc2 kinase. Several alternative splice isoforms of plectin are known to exist. Mutations in human plectin are known to cause epidermolysis bullosa simplex with muscular dystrophy (EBS-MD). |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHCIP |
| WB:1:1,000 IHC:1:100-1:500 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | EBS1 antibody EBSO antibody HD1 antibody Hemidesmosomal protein 1 antibody PCN antibody pleC antibody PLEC_HUMAN antibody PLEC1 antibody PLEC1b antibody Plectin 1 antibody Plectin 1 intermediate filament binding protein 500kDa antibody Plectin 6 antibody Plectin antibody Plectin-1 antibody PLTN antibody |
|---|---|
| Molecular Weight(MW) | 531 kDa |
| Cellular Localization | Cytoplasm, Cell junction. |
Application
Fig1: Immunohistochemical analysis of paraffin-embedded rat skeletal muscle tissue using anti-Plectin antibody. Counter stained with hematoxylin.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue using anti-Plectin antibody. Counter stained with hematoxylin.| Positive Control | Rat skeletal muscle tissue, mouse skeletal muscle tissue. |
|---|---|
| Application Notes | WB:1:1,000 IHC:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
