Application
Fig1: Western blot analysis of NEDD4-2 on Jurkat cells lysates using anti-NEDD4-2 antibody at 1/1,000 dilution.| Product Name | NEDD4-2 [SN73-03] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | E3 ubiquitin protein ligase NEDD4 like protein antibody E3 ubiquitin-protein ligase NEDD4-like antibody KIAA0439 antibody NED4L_HUMAN antibody NEDD4 2 antibody NEDD4 2c antibody Nedd4-2 antibody NEDD4-2a antibody NEDD4.2 antibody NEDD4b antibody NEDD4L antibody NEDD4La antibody NEDD4Lb antibody NEDD4Lc antibody NEDD4Ld antibody NEDD4Le antibody NEDD4Lf antibody NEDD4Lg antibody NEDD4Lh antibody NEDL3 antibody Neural precursor cell expressed developmentally down regulated 4 like E3 ubiquitin protein ligase antibody Neural precursor cell expressed, developmentally down regulated 4 like antibody RSP5 antibody Ubiquitin protein ligase Rsp5 antibody |
| Product description | NEDD4-L (neural precursor cell expressed, developmentally down-regulated 4-like), also known as RSP5, NEDD4-2 or NEDL3, is a 975 amino acid protein that localizes to the cytoplasm and contains four WW domains, one HECT domain and one C2 domain. Expressed ubiquitously with highest expression in pancreas, prostate and kidney, NEDD4-L functions as an E3 ubiquitin-protein ligase that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme and transfers that ubiquitin residue to substrates targeted for degradation. Through its ability to ubiquitinate and induce the proteasome-dependent degradation of proteins such as Smad2 and TGFβ RII, NEDD4-L is thought to inhibit the TGFβ signaling pathway, thereby regulating the signaling pathways that control cell growth and differentiation. NEDD4-L is expressed as eight isoforms due to alternative splicing events. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIP |
| WB:1:1,000-1:5,000 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | E3 ubiquitin protein ligase NEDD4 like protein antibody
E3 ubiquitin-protein ligase NEDD4-like antibody
KIAA0439 antibody
NED4L_HUMAN antibody
NEDD4 2 antibody
NEDD4 2c antibody
Nedd4-2 antibody
NEDD4-2a antibody
NEDD4.2 antibody
NEDD4b antibody
NEDD4L antibody
NEDD4La antibody
NEDD4Lb antibody
NEDD4Lc antibody
NEDD4Ld antibody
NEDD4Le antibody
NEDD4Lf antibody
NEDD4Lg antibody
NEDD4Lh antibody
NEDL3 antibody
Neural precursor cell expressed developmentally down regulated 4 like E3 ubiquitin protein ligase antibody
Neural precursor cell expressed developmentally down regulated 4 like antibody RSP5 antibody Ubiquitin protein ligase Rsp5 antibody |
|---|---|
| Molecular Weight(MW) | 112 kDa |
| Cellular Localization | Cytoplasm. |
Application
Fig1: Western blot analysis of NEDD4-2 on Jurkat cells lysates using anti-NEDD4-2 antibody at 1/1,000 dilution.| Positive Control | Jurkat. |
|---|---|
| Application Notes | WB:1:1,000-1:5,000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
