Application
Fig1: Western blot analysis of Cytokeratin 2e on human skin lysates using anti-Cytokeratin 2e antibody at 1/1,000 dilution.Application
Fig2: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Cytokeratin 2e antibody. Counter stained with hematoxylin.| Product Name | Cytokeratin 2e [JJ201-8] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CK 2e antibody Cytokeratin-2e antibody Epithelial keratin-2e antibody K2e antibody Keratin type II cytoskeletal 2 epidermal antibody Keratin-2 epidermis antibody KRT2 antibody KRT2A antibody KRT2E antibody Type-II keratin Kb2 antibody |
| Product description | The keratin multigene family is made of "soft" epithelial cytokeratins and "hard" hair keratins. While the epithelial cytokeratins are involved in the layering and formation of epithelia, the hair keratins are responsible for creating nails and hair. There are two types of keratins: the acidic class I keratin proteins and the basic/neutral class II keratin proteins. Keratin 2 (KRT2), also known as Keratin type II cytoskeletal 2 epidermal, Keratin-2e (K2e), KRTE, Cytokeratin-2e (CK-2e), KRT2A or KRT2E, is a 639 amino acid class II epithelial Keratin protein belonging to the intermediate filament family. Encoded by a gene that maps to human chromosome 12q13.13, Keratin 2 functions in epidermal keratinocyte activation and proliferation, and plays a part in terminal cornification. Highly expressed in upper epithelial tissues, Keratin 2 forms heterotetramers with two class I Keratins and another class II Keratin. Defects in Keratin 2 have been linked to ichthyosis bullosa of Siemens (IBS), a rare autosomal dominant skin disorder. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:1,000 IHC:1:50-1:200 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | CK 2e antibody Cytokeratin-2e antibody Epithelial keratin-2e antibody K2e antibody Keratin type II cytoskeletal 2 epidermal antibody Keratin-2 epidermis antibody KRT2 antibody KRT2A antibody KRT2E antibody Type-II keratin Kb2 antibody |
|---|---|
| Molecular Weight(MW) | 65 kDa |
| Cellular Localization | Cytoplasm, Membrane, Nucleus. |
| SwissProt ID | P35908 |
|---|
Application
Fig1: Western blot analysis of Cytokeratin 2e on human skin lysates using anti-Cytokeratin 2e antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Cytokeratin 2e antibody. Counter stained with hematoxylin.| Positive Control | Human skin tissue, human tonsil tissue. |
|---|---|
| Application Notes | WB:1:1,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
