Application
Fig1: Western blot analysis of HMGCR on Hela cells lysates using anti-HMGCR antibody at 1/1,000 dilution.| Product Name | HMGCR [JF0981] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 3 hydroxy 3 methylglutaryl CoA reductase antibody 3 hydroxy 3 methylglutaryl Coenzyme A reductase antibody 3 hydroxymethylglutaryl CoA reductase antibody 3-hydroxy-3-methylglutaryl CoA reductase (NADPH) antibody 3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody 3H3M antibody HMDH_HUMAN antibody HMG CoA reductase antibody HMG CoAR antibody HMG-CoA reductase antibody Hmgcr antibody Hydroxymethylglutaryl CoA reductase antibody LDLCQ3 antibody MGC103269 antibody Red antibody |
| Product description | The human enzyme hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) limits the rate of cholesterol synthesis, a necessary process for cellular growth, in liver tissue. Phosphorylation of HMGCR inactivates the enzyme, which occurs via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Inhibitors of HMGCR (statins) exert anti-inflammatory effects and decrease the frequency of cardiovascular events by lowering plasma cholesterol. Additionally, intermediate products along the pathway catalyzed by HMGCR, which modulate signal transducing proteins such as Ras, provide possible ties between HMGCR regulation and new chemotherapeutic methods. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIP |
| WB:1:1,000-1:2,000 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | 3 hydroxy 3 methylglutaryl CoA reductase antibody 3 hydroxy 3 methylglutaryl Coenzyme A reductase antibody 3 hydroxymethylglutaryl CoA reductase antibody 3-hydroxy-3-methylglutaryl CoA reductase (NADPH) antibody 3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody 3H3M antibody HMDH_HUMAN antibody HMG CoA reductase antibody HMG CoAR antibody HMG-CoA reductase antibody Hmgcr antibody Hydroxymethylglutaryl CoA reductase antibody LDLCQ3 antibody MGC103269 antibody Red antibody |
|---|---|
| Molecular Weight(MW) | 97 kDa |
| Cellular Localization | Endoplasmic reticulum membrane. |
Application
Fig1: Western blot analysis of HMGCR on Hela cells lysates using anti-HMGCR antibody at 1/1,000 dilution.| Positive Control | Hela. |
|---|---|
| Application Notes | WB:1:1,000-1:2,000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
