Application
Fig1: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Midkine antibody. Counter stained with hematoxylin.Application
Fig2: Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Midkine antibody. Counter stained with hematoxylin.| Product Name | Midkine [JF096-5] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Amphiregulin associated protein antibody Amphiregulin-associated protein antibody ARAP antibody FLJ27379 antibody Mdk antibody Midgestation and kidney protein antibody Midkine antibody MK 1 antibody MK antibody MK_HUMAN antibody MK1 antibody NEGF 2 antibody NEGF2 antibody Neurite growth promoting factor 2 antibody Neurite outgrowth promoting protein antibody Neurite outgrowth-promoting factor 2 antibody Neurite outgrowth-promoting protein antibody Retinoic acid inducible factor antibody |
| Product description | Midkine, or MK, is a heparin-binding molecule involved in the regulation of growth and differentiation during embryogenesis. MK expression is tightly regulated during embryonic development by steroid receptors of the retinoic acid superfamily. The mature human MK protein is 118 amino acids in length and contains five intrachain disulfide bonds. MK is a non-glycosylated protein that shows greater than 87% identity between human and mouse. The carboxy-terminus of MK contains the principle heparin-binding site and the molecule’s neurite-promoting sequences; both the amino- and carboxy-terminal sequences are required for the molecule’s neurotrophic properties. An association between overexpression of MK and colon adenocarcinoma has been shown in families suffering from familial polyposis. In addition, MK functions to enhance the activity of plasminogen activator (PA). |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHCIP |
| WB:1:500-1:1,000 IHC:1:50-1:200 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | Amphiregulin associated protein antibody Amphiregulin-associated protein antibody ARAP antibody FLJ27379 antibody Mdk antibody Midgestation and kidney protein antibody Midkine antibody MK 1 antibody MK antibody MK_HUMAN antibody MK1 antibody NEGF 2 antibody NEGF2 antibody Neurite growth promoting factor 2 antibody Neurite outgrowth promoting protein antibody Neurite outgrowth-promoting factor 2 antibody Neurite outgrowth-promoting protein antibody Retinoic acid inducible factor antibody |
|---|---|
| Molecular Weight(MW) | 16 kDa |
| Cellular Localization | Secreted. |
| SwissProt ID | P21741 |
|---|
Application
Fig1: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Midkine antibody. Counter stained with hematoxylin.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Midkine antibody. Counter stained with hematoxylin.| Positive Control | Human liver cancer tissue, human pancreas tissue. |
|---|---|
| Application Notes | WB:1:500-1:1,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
