Application
Fig1: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD80 antibody. Counter stained with hematoxylin.| Product Name | CD80 [JF100-4] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Activation B7-1 antigen antibody B lymphocyte activation antigen B7 antibody B7 antibody B7-1 antibody B7-1 antigen antibody B7.1 antibody BB1 antibody CD28 antigen ligand 1 antibody CD28LG antibody CD28LG1 antibody CD80 antibody CD80 antigen (CD28 antigen ligand 1, B7-1 antigen) antibody CD80 antigen antibody CD80 molecule antibody CD80_HUMAN antibody Costimulatory factor CD80 antibody costimulatory molecule variant IgV-CD80 antibody CTLA-4 counter-receptor B7.1 antibody LAB7 antibody T-lymphocyte activation antigen CD80 antibody |
| Product description | T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells, bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counterreceptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:1,000 IHC:1:50-1:100 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | Activation B7-1 antigen antibody
B lymphocyte activation antigen B7 antibody
B7 antibody
B7-1 antibody
B7-1 antigen antibody
B7.1 antibody
BB1 antibody
CD28 antigen ligand 1 antibody
CD28LG antibody
CD28LG1 antibody
CD80 antibody
CD80 antigen (CD28 antigen ligand 1 B7-1 antigen) antibody CD80 antigen antibody CD80 molecule antibody CD80_HUMAN antibody Costimulatory factor CD80 antibody costimulatory molecule variant IgV-CD80 antibody CTLA-4 counter-receptor B7.1 antibody LAB7 antibody T-lymphocyte activation antigen CD80 antibody |
|---|---|
| Molecular Weight(MW) | 60 kDa |
| Cellular Localization | Membrane. |
| SwissProt ID | P33681 |
|---|
Application
Fig1: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD80 antibody. Counter stained with hematoxylin.| Positive Control | Human tonsil tissue. |
|---|---|
| Application Notes | WB:1:500-1:1,000 IHC:1:50-1:100 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
