Application
Fig1: Western blot analysis of FOXA2 on HT-29 cells lysates using anti-FOXA2 antibody at 1/500 dilution.| Product Name | FOXA2 [JM10-64] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Forkhead box A2 antibody Forkhead box protein A2 antibody FOX A2 antibody foxa2 antibody FOXA2_HUMAN antibody Hepatic nuclear factor 3 beta antibody Hepatocyte nuclear factor 3 antibody Hepatocyte nuclear factor 3 beta antibody Hepatocyte nuclear factor 3-beta antibody HNF 3B antibody HNF-3-beta antibody HNF-3B antibody HNF3B antibody MGC19807 antibody TCF 3B antibody TCF-3B antibody TCF3B antibody Transcription factor 3B antibody |
| Product description | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBICC/IF |
| WB:1:1,000-1:5,000 ICC:1:50-1:200 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | Forkhead box A2 antibody Forkhead box protein A2 antibody FOX A2 antibody foxa2 antibody FOXA2_HUMAN antibody Hepatic nuclear factor 3 beta antibody Hepatocyte nuclear factor 3 antibody Hepatocyte nuclear factor 3 beta antibody Hepatocyte nuclear factor 3-beta antibody HNF 3B antibody HNF-3-beta antibody HNF-3B antibody HNF3B antibody MGC19807 antibody TCF 3B antibody TCF-3B antibody TCF3B antibody Transcription factor 3B antibody |
|---|---|
| Molecular Weight(MW) | 52 kDa |
| Cellular Localization | Nucleus. Cytoplasm. |
| SwissProt ID | Q9Y261 |
|---|
Application
Fig1: Western blot analysis of FOXA2 on HT-29 cells lysates using anti-FOXA2 antibody at 1/500 dilution.| Positive Control | HT29. |
|---|---|
| Application Notes | WB:1:1,000-1:5,000 ICC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
