Application
Fig1: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti- MHC Class II antibody. Counter stained with hematoxylin.Application
Fig2: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti- MHC Class II antibody. Counter stained with hematoxylin.| Product Name | MHC Class II [JA10-94] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | D6S221E antibody DMA antibody DMB antibody DP beta 1 antibody DP beta 1 chain antibody DP(W4) beta chain antibody DPB 1 antibody DPB1 antibody DPB1_HUMAN antibody DRB antibody H2Ea antibody HLA class II histocompatibility antigen antibody HLA class II histocompatibility antigen DM beta chain antibody HLA class II histocompatibility antigen, DP beta 1 chain antibody HLA class II histocompatibility antigen, DP(W4) beta chain antibody HLA DMB antibody HLA DP1A antibody HLA DPB1 antibody HLA SB alpha chain antibody HLA-A antibody HLA-A histocompatibility type antibody HLA-DP antibody HLA-DP histocompatibility type, beta-1 subunit antibody HLA-DP1B antibody HLA-DPB antibody HLA-DPB1 antibody HLADM antibody HLADP1B antibody HLASB antibody HLASB histocompatibility type antibody Human MHC class II HLA SB alpha antibody LA class II histocompatibility antigen DP alpha 1 chain antibody Major histocompatibility complex class II antibody Major histocompatibility complex class II DP alpha 1 antibody Major histocompatibility complex class II DP beta 1 antibody Major histocompatibility complex, class I, A antibody MHC class II antigen DMB antibody MHC class II antigen DPB1 antibody MHC class II DP3 alpha antibody MHC class II DPA1 antibody MHC class II HLA-DP-beta-1 antibody MHC DPB1 antibody MHC HLA DPB1 antibody PLT1 antibody Primed lymphocyte test 1 antibody RING6 antibody RING7 antibody |
| Product description | Major histocompatibility complex (MHC) molecules, also designated human leukocyte antigen (HLA) molecules, are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an α or heavy chain and β-2-Microglobulin, a non-covalently associated protein. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically eight to ten residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a non-covalent complex of an α and β chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumu-lating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIPICC/IFIHC |
| WB:1:500-1:1,000 IP:1:10-1:50 ICC IHC:1:50-1:200 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | D6S221E antibody
DMA antibody
DMB antibody
DP beta 1 antibody
DP beta 1 chain antibody
DP(W4) beta chain antibody
DPB 1 antibody
DPB1 antibody
DPB1_HUMAN antibody
DRB antibody
H2Ea antibody
HLA class II histocompatibility antigen antibody
HLA class II histocompatibility antigen DM beta chain antibody
HLA class II histocompatibility antigen DP beta 1 chain antibody HLA class II histocompatibility antigen DP(W4) beta chain antibody HLA DMB antibody HLA DP1A antibody HLA DPB1 antibody HLA SB alpha chain antibody HLA-A antibody HLA-A histocompatibility type antibody HLA-DP antibody HLA-DP histocompatibility type beta-1 subunit antibody HLA-DP1B antibody HLA-DPB antibody HLA-DPB1 antibody HLADM antibody HLADP1B antibody HLASB antibody HLASB histocompatibility type antibody Human MHC class II HLA SB alpha antibody LA class II histocompatibility antigen DP alpha 1 chain antibody Major histocompatibility complex class II antibody Major histocompatibility complex class II DP alpha 1 antibody Major histocompatibility complex class II DP beta 1 antibody Major histocompatibility complex class I A antibody MHC class II antigen DMB antibody MHC class II antigen DPB1 antibody MHC class II DP3 alpha antibody MHC class II DPA1 antibody MHC class II HLA-DP-beta-1 antibody MHC DPB1 antibody MHC HLA DPB1 antibody PLT1 antibody Primed lymphocyte test 1 antibody RING6 antibody RING7 antibody |
|---|---|
| Molecular Weight(MW) | 29 kDa |
| Cellular Localization | Cell membrane. Endoplasmic reticulum membrane. |
| SwissProt ID | P04440 |
|---|
Application
Fig1: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti- MHC Class II antibody. Counter stained with hematoxylin.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti- MHC Class II antibody. Counter stained with hematoxylin.| Positive Control | Human tonsil tissue, human spleen tissue. |
|---|---|
| Application Notes | WB:1:500-1:1,000 IP:1:10-1:50 ICC IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
