Application
Fig1: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti- Hepcidin antibody. Counter stained with hematoxylin.Application
Fig2: Immunohistochemical analysis of paraffin-embedded rat heart tissue using anti- Hepcidin antibody. Counter stained with hematoxylin.Application
Fig3: Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti- Hepcidin antibody. Counter stained with hematoxylin.| Product Name | Hepcidin [JA11-27] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Hamp antibody HEPC antibody HEPC_HUMAN antibody Hepc20 antibody Hepc25 antibody Hepcidin-20 antibody HFE2B antibody LEAP-1 antibody LEAP1 antibody Liver-expressed antimicrobial peptide 1 antibody PLTR antibody Putative liver tumor regressor antibody |
| Product description | Hepcidin, also known as HAMP, HEPC, LEAP1 or HFE2B, is an 84 amino acid secreted protein that regulates iron-related signaling events. Highly expressed in liver with lower expression in heart, brain, lung, prostate and thyroid, hepcidin is thought to maintain iron homeostasis and, in conjunction with the HFE protein (a protein that is defective in hereditary hemochromatosis), may mediate both iron storage in macrophages and intestinal iron absorption. Additionally, hepcidin has strong antimicrobial activity against gram-positive and gram-negative bacteria, as well as certain yeast strains, suggesting that hepcidin may play a crucial role in staving off bacterial infections. Defects in the gene encoding hepcidin are the cause of hemochromatosis type 2B (also known as juvenile hemochromatosis), an early-onset autosomal recessive disorder that results in severe iron overload and is characterized by hepatic fibrosis, hypogonadotrophic hypogonadism and cardiomyopathy. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:1,000 IHC:1:50-1:200 |
|
| Species Reactivity | HumanRat |
| Concentration | 1mg/ml |
| Alternative Names | Hamp antibody HEPC antibody HEPC_HUMAN antibody Hepc20 antibody Hepc25 antibody Hepcidin-20 antibody HFE2B antibody LEAP-1 antibody LEAP1 antibody Liver-expressed antimicrobial peptide 1 antibody PLTR antibody Putative liver tumor regressor antibody |
|---|---|
| Molecular Weight(MW) | 3 kDa |
| Cellular Localization | Secreted. |
| SwissProt ID | P81172 |
|---|
Application
Fig1: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti- Hepcidin antibody. Counter stained with hematoxylin.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded rat heart tissue using anti- Hepcidin antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti- Hepcidin antibody. Counter stained with hematoxylin.| Positive Control | Human liver tissue, rat heart tissue, rat brain tissue. |
|---|---|
| Application Notes | WB:1:500-1:1,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
