Application
Fig1: Western blot analysis of Cytochrome P450 3A4 on human liver tissue lysate using anti-Cytochrome P450 3A4 antibody at 1/1,000 dilution.Application
Fig2: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Cytochrome P450 3A4 antibody. Counter stained with hematoxylin.| Product Name | Cytochrome P450 3A4 [JA11-33] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 1,8-cineole 2-exo-monooxygenase antibody Albendazole monooxygenase antibody Albendazole sulfoxidase antibody CP33 antibody CP34 antibody CP3A4_HUMAN antibody CYP3 antibody CYP3A antibody CYP3A3 antibody CYP3A4 antibody CYPIIIA3 antibody CYPIIIA4 antibody Cytochrome P450 3A3 antibody Cytochrome P450 3A4 antibody Cytochrome P450 family 3 subfamily A polypeptide 4 antibody Cytochrome P450 HLp antibody Cytochrome P450 NF-25 antibody Cytochrome P450 subfamily IIIA polypeptide 4 antibody cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 antibody cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 antibody Cytochrome P450-PCN1 antibody Glucocorticoid inducible P450 antibody HLP antibody MGC126680 antibody NF 25 antibody NF25 antibody Nifedipine oxidase antibody P450 III steroid inducible antibody P450 PCN1 antibody P450, family III antibody P450C3 antibody P450PCN1 antibody Quinine 3 monooxygenase antibody Quinine 3-monooxygenase antibody Taurochenodeoxycholate 6 alpha hydroxylase antibody Taurochenodeoxycholate 6-alpha-hydroxylase antibody |
| Product description | CYP3A, the most abundant p450 enzyme in human liver, is responsible for the metabolism of more than 50% of the clinical test & lt; RTI ID = 0.0 & gt; (cYP3A) genes encode monooxygenases-enzymes which catalyze drug metabolism and the synthesis of cholesterol, steroids and other lipids. CYP3A family members localize in organs that associate with drug disposition, including the liver, gastrointestinal tract and kidney. The CYP3A cluster maps to gene locus 7q22.1 and consists of four genes (CYP3A4, CYP3A5, CYP3A7 and CYP3A43) and two pseudogenes ( CYP3A4 is abundant in the endoplasmic reticulum of liver cells and upper intestinal enterocytes. CYP3A4 expression is isducible by glucocorticoids pharmacological agents. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHCIP |
| WB:1:500-1:1,000 IHC:1:50-1:200 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | 1 8-cineole 2-exo-monooxygenase antibody Albendazole monooxygenase antibody Albendazole sulfoxidase antibody CP33 antibody CP34 antibody CP3A4_HUMAN antibody CYP3 antibody CYP3A antibody CYP3A3 antibody CYP3A4 antibody CYPIIIA3 antibody CYPIIIA4 antibody Cytochrome P450 3A3 antibody Cytochrome P450 3A4 antibody Cytochrome P450 family 3 subfamily A polypeptide 4 antibody Cytochrome P450 HLp antibody Cytochrome P450 NF-25 antibody Cytochrome P450 subfamily IIIA polypeptide 4 antibody cytochrome P450 subfamily IIIA (niphedipine oxidase) polypeptide 3 antibody cytochrome P450 subfamily IIIA (niphedipine oxidase) polypeptide 4 antibody Cytochrome P450-PCN1 antibody Glucocorticoid inducible P450 antibody HLP antibody MGC126680 antibody NF 25 antibody NF25 antibody Nifedipine oxidase antibody P450 III steroid inducible antibody P450 PCN1 antibody P450 family III antibody P450C3 antibody P450PCN1 antibody Quinine 3 monooxygenase antibody Quinine 3-monooxygenase antibody Taurochenodeoxycholate 6 alpha hydroxylase antibody Taurochenodeoxycholate 6-alpha-hydroxylase antibody |
|---|---|
| Molecular Weight(MW) | 57 kDa |
| Cellular Localization | Endoplasmic reticulum membrane. Microsome membrane. |
| SwissProt ID | P08684 |
|---|
Application
Fig1: Western blot analysis of Cytochrome P450 3A4 on human liver tissue lysate using anti-Cytochrome P450 3A4 antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Cytochrome P450 3A4 antibody. Counter stained with hematoxylin.| Positive Control | Human liver. |
|---|---|
| Application Notes | WB:1:500-1:1,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
