Application
Fig1: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-DOPA Decarboxylase antibody. Counter stained with hematoxylin.Application
Fig2: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-DOPA Decarboxylase antibody. Counter stained with hematoxylin.| Product Name | DOPA Decarboxylase [JA53-16] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AADC antibody Aromatic L Amino Acid Decarboxylase antibody Aromatic-L-amino-acid decarboxylase antibody Ddc antibody DDC_HUMAN antibody DOPA decarboxylase (aromatic L-amino acid decarboxylase) antibody DOPA decarboxylase antibody |
| Product description | DOPA decarboxylase (DDC), also designated aromatic-L-amino-acid decarboxylase (AADC) belongs to the group II decarboxylase family of proteins. DDC, which can form a homodimer, is an important protein in the catecholamine biosynthesis pathway. DDC acts as a catalyst in the decarboxylation of L-5-hydroxytryptophan to serotonin, L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-tryptophan to tryptamine. Defects in the gene encoding for DDC may cause the autosomal recessive disorder AADC deficiency. AADC deficiency is an early onset inborn error in neurotransmitter metabolism which can lead to catecholamine and serotonin deficiency. This causes poor feeding, psychomotor and developmental delays, lethargy, ptosis, gastrointestinal disturbances and hypothermia. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:500~1:2000 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | AADC antibody Aromatic L Amino Acid Decarboxylase antibody Aromatic-L-amino-acid decarboxylase antibody Ddc antibody DDC_HUMAN antibody DOPA decarboxylase (aromatic L-amino acid decarboxylase) antibody DOPA decarboxylase antibody |
|---|---|
| Molecular Weight(MW) | 53 kDa |
| Cellular Localization | Cytoplasm. |
Application
Fig1: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-DOPA Decarboxylase antibody. Counter stained with hematoxylin.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-DOPA Decarboxylase antibody. Counter stained with hematoxylin.| Positive Control | Human liver tissue, human kidney tissue. |
|---|---|
| Application Notes | WB:1:500~1:2000 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
