Application
Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-JAK3 antibody. Counter stained with hematoxylin.Application
Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-JAK3 antibody. Counter stained with hematoxylin.Application
Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-JAK3 antibody. Counter stained with hematoxylin.| Product Name | JAK3 [JM66-31] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | EC 2.7.10.2 antibody JAK 3 antibody JAK L antibody JAK-3 antibody Jak3 antibody JAK3 HUMAN antibody JAK3_HUMAN antibody JAKL antibody Janus kinase 3 (a protein tyrosine kinase, leukocyte) antibody Janus kinase 3 antibody Janus Kinase3 antibody L JAK antibody L-JAK antibody Leukocyte janus kinase antibody LJAK antibody Protein tyrosine kinase leukocyte antibody Tyrosine protein kinase JAK3 antibody Tyrosine-protein kinase JAK3 antibody |
| Product description | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHCICC |
| WB:1:500-1:1,000 IHC:1:50-1:200 ICC:1:50-1:100 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | EC 2.7.10.2 antibody
JAK 3 antibody
JAK L antibody JAK-3 antibody Jak3 antibody JAK3 HUMAN antibody JAK3_HUMAN antibody JAKL antibody Janus kinase 3 (a protein tyrosine kinase leukocyte) antibody Janus kinase 3 antibody Janus Kinase3 antibody L JAK antibody L-JAK antibody Leukocyte janus kinase antibody LJAK antibody Protein tyrosine kinase leukocyte antibody Tyrosine protein kinase JAK3 antibody Tyrosine-protein kinase JAK3 antibody |
|---|---|
| Molecular Weight(MW) | -- |
| Cellular Localization | Endomembrane system. |
| SwissProt ID | P52333 |
|---|
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-JAK3 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-JAK3 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-JAK3 antibody. Counter stained with hematoxylin.| Positive Control | Hela, Human tonsil tissue, human spleen tissue. |
|---|---|
| Application Notes | WB:1:500-1:1,000 IHC:1:50-1:200 ICC:1:50-1:100 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
