Application
Fig1: ICC staining JAK2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.Application
Fig2: Immunohistochemical analysis of paraffin-embedded rat liver tissue using anti-JAK2 antibody. Counter stained with hematoxylin.Application
Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-JAK2 antibody. Counter stained with hematoxylin.Application
Fig4: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-JAK2 antibody. Counter stained with hematoxylin.Application
Fig5: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-JAK2 antibody. Counter stained with hematoxylin.Application
Fig6: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-JAK2 antibody. Counter stained with hematoxylin.| Product Name | JAK2 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | JAK 2 antibody JAK-2 antibody JAK2 antibody JAK2_HUMAN antibody Janus Activating Kinase 2 antibody Janus kinase 2 (a protein tyrosine kinase) antibody Janus kinase 2 antibody JTK 10 antibody JTK10 antibody kinase Jak2 antibody OTTHUMP00000043260 antibody THCYT3 antibody Tyrosine protein kinase JAK2 antibody Tyrosine-protein kinase JAK2 antibody |
| Product description | JAK2 (Janus kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies. |
| Immunogen | Peptide. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICCIHC |
| ICC:1:50-1:200 IHC:1:50-1:200 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | JAK 2 antibody JAK-2 antibody JAK2 antibody JAK2_HUMAN antibody Janus Activating Kinase 2 antibody Janus kinase 2 (a protein tyrosine kinase) antibody Janus kinase 2 antibody JTK 10 antibody JTK10 antibody kinase Jak2 antibody OTTHUMP00000043260 antibody THCYT3 antibody Tyrosine protein kinase JAK2 antibody Tyrosine-protein kinase JAK2 antibody |
|---|---|
| Molecular Weight(MW) | 131 kDa |
| Cellular Localization | Endomembrane system. Nucleus. |
Application
Fig1: ICC staining JAK2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded rat liver tissue using anti-JAK2 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-JAK2 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-JAK2 antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-JAK2 antibody. Counter stained with hematoxylin.
Application
Fig6: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-JAK2 antibody. Counter stained with hematoxylin.| Positive Control | Hela, rat liver tissue, human tonsil tissue, human colon cancer tissue, human kidney tissue, mouse kidney tissue. |
|---|---|
| Application Notes | ICC:1:50-1:200 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide. |
