Application
Fig5: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-ATM (phospho S1981) antibody. Counter stained with hematoxylin.Application
Fig5: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-ATM (phospho S1981) antibody. Counter stained with hematoxylin.Application
Fig5: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-ATM (phospho S1981) antibody. Counter stained with hematoxylin.Application
Fig5: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-ATM (phospho S1981) antibody. Counter stained with hematoxylin.Application
Fig5: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-ATM (phospho S1981) antibody. Counter stained with hematoxylin.| Product Name | ATM (phospho S1981) [JM93-25] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | A-T mutated antibody A-T mutated homolog antibody AT mutated antibody AT1 antibody ATA antibody Ataxia telangiectasia mutated antibody Ataxia telangiectasia mutated gene antibody Ataxia telangiectasia mutated homolog (human) antibody Ataxia telangiectasia mutated homolog antibody ATC antibody ATD antibody ATDC antibody ATE antibody ATM antibody ATM serine/threonine kinase antibody ATM_HUMAN antibody DKFZp781A0353 antibody MGC74674 antibody OTTHUMP00000232981 antibody Serine protein kinase ATM antibody Serine-protein kinase ATM antibody Serine/threonine-protein kinase ATM antibody Tefu antibody TEL1 antibody TEL1, telomere maintenance 1, homolog antibody TELO1 antibody Telomere fusion protein antibody |
| Product description | Serine / threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thus acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST] -Q. Phosphorylates 'Ser-139' of histone variant H2AX / H2AFX at double strand breaks (DSBs), recover equilibrium DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain Allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin , Soaccessability to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as A genre of activation of ABL1 and SAPK. May play a role in vesicle and / or protein transport. Could play A role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Ser1981 of human ATM. |
| Modification | p-S1981 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBICC/IFIHCIP |
| WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:100 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | A-T mutated antibody
A-T mutated homolog antibody
AT mutated antibody
AT1 antibody
ATA antibody
Ataxia telangiectasia mutated antibody
Ataxia telangiectasia mutated gene antibody
Ataxia telangiectasia mutated homolog (human) antibody
Ataxia telangiectasia mutated homolog antibody
ATC antibody
ATD antibody
ATDC antibody
ATE antibody
ATM antibody
ATM serine/threonine kinase antibody
ATM_HUMAN antibody
DKFZp781A0353 antibody
MGC74674 antibody
OTTHUMP00000232981 antibody
Serine protein kinase ATM antibody
Serine-protein kinase ATM antibody
Serine/threonine-protein kinase ATM antibody
Tefu antibody
TEL1 antibody
TEL1 telomere maintenance 1 homolog antibody TELO1 antibody Telomere fusion protein antibody |
|---|---|
| Molecular Weight(MW) | 351 kDa |
| Cellular Localization | Nucleus. Cytoplasmic vesicle. |
| SwissProt ID | Q13315 |
|---|
Application
Fig5: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-ATM (phospho S1981) antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-ATM (phospho S1981) antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-ATM (phospho S1981) antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-ATM (phospho S1981) antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-ATM (phospho S1981) antibody. Counter stained with hematoxylin.| Positive Control | HepG2, Hela, SH-SY5Y, human tonsil tissue, human breast cancer tissue. |
|---|---|
| Application Notes | WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:100 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
