Application
Fig1: Western blot analysis of Klotho on human serum lysate using anti-Klotho antibody at 1/1,000 dilution.Application
Fig2: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Klotho antibody. Counter stained with hematoxylin.Application
Fig3: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-Klotho antibody. Counter stained with hematoxylin.| Product Name | Klotho |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Kl antibody KLOT_HUMAN antibody Klotho peptide antibody |
| Product description | May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2,000 IHC:1:50-1:200 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | Kl antibody KLOT_HUMAN antibody Klotho peptide antibody |
|---|---|
| Cellular Localization | Secreted. Cell membrane. |
Application
Fig1: Western blot analysis of Klotho on human serum lysate using anti-Klotho antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Klotho antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-Klotho antibody. Counter stained with hematoxylin.| Positive Control | Human serum lysate, human kidney tissue, mouse kidney tissue. |
|---|---|
| Application Notes | WB:1:500-1:2,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
