Application
Fig1: Western blot analysis of BDKRB2 on MCF-7 cell lysate using anti-BDKRB2 antibody at 1/500 dilution.Application
Fig2: Flow cytometric analysis of SH-SY5Y cells with BDKRB2 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).| Product Name | BDKRB2 [JU39-04] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | B2 antibody B2 bradykinin receptor antibody B2BKR antibody B2BRA antibody B2R antibody BDKR B2 antibody BDKRB 2 antibody BDKRB2 antibody BK 2 antibody BK 2 receptor antibody BK R2 antibody BK-2 receptor antibody BK2 antibody BK2 receptor antibody BK2R antibody BKR 2 antibody BKR2 antibody BKRB2_HUMAN antibody BR B2 antibody Bradykinin receptor B2 antibody Bradykinin receptor beta 2 antibody BRB 2 antibody BRB2 antibody DKFZp686O088 antibody Kinin B2 antibody |
| Product description | Kinins are important biologically active peptides that mediate cardiovascular homeostasis, inflammation and nociception. Bradykinin, the major effector peptide of the kallikrein-kinin system, is regulated by angiotensin-converting enzyme (ACE), which degrades the peptide. Bradykinin normally exerts its effects through the activation of two seven transmembrane G-protein coupled receptors, named B1 and B2. The B2 receptor is constitutively expressed and preferentially binds full length bradykinin. Deletion of the B2 receptor leads to salt-sensitive hypertension and altered nociception in mice. The B1 receptor binds to derivatives of bradykinin and kallidin, which are produced by carboxypeptidase action to generate the products des-Arg9-bradykinin and des-Arg10-kallidin, respectively. The expression of the B1 receptor is inducible by inflammatory mediators, such as bacterial lipopolysaccharide (LPS) and cytokines. The B1 and B2 receptors represent potential therapeutic targets for treatment of inflammatory disorders and cardiovascular diseases. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBFCIP |
| WB:1:500-1:1,000 FC:1:50-1:100 IP:1:10-1:50 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | B2 antibody B2 bradykinin receptor antibody B2BKR antibody B2BRA antibody B2R antibody BDKR B2 antibody BDKRB 2 antibody BDKRB2 antibody BK 2 antibody BK 2 receptor antibody BK R2 antibody BK-2 receptor antibody BK2 antibody BK2 receptor antibody BK2R antibody BKR 2 antibody BKR2 antibody BKRB2_HUMAN antibody BR B2 antibody Bradykinin receptor B2 antibody Bradykinin receptor beta 2 antibody BRB 2 antibody BRB2 antibody DKFZp686O088 antibody Kinin B2 antibody |
|---|---|
| Molecular Weight(MW) | 80 kDa |
| Cellular Localization | Cell membrane. |
| SwissProt ID | P30411 |
|---|
Application
Fig1: Western blot analysis of BDKRB2 on MCF-7 cell lysate using anti-BDKRB2 antibody at 1/500 dilution.
Application
Fig2: Flow cytometric analysis of SH-SY5Y cells with BDKRB2 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).| Positive Control | MCF-7, SH-SY5Y. |
|---|---|
| Application Notes | WB:1:500-1:1,000 FC:1:50-1:100 IP:1:10-1:50 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
