Application
Fig1: Western blot analysis of Mast Cell Chymase on rat spleen and mouse spleen tissue lysates using anti-Mast Cell Chymase antibody at 1/500 dilution.Application
Fig2: Immunohistochemical analysis of paraffin-embedded human skin tissue using anti- Mast Cell Chymase antibody. Counter stained with hematoxylin.Application
Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti- Mast Cell Chymase antibody. Counter stained with hematoxylin.| Product Name | Mast Cell Chymase [JB74-32] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Alpha-chymase antibody Chymase 1 antibody Chymase 1 mast cell antibody chymase 1 preproprotein transcript E antibody chymase 1 preproprotein transcript I antibody Chymase antibody Chymase, heart antibody Chymase, mast cell antibody CMA1 antibody CMA1_HUMAN antibody CYH antibody CYM antibody EC 3.4.21.39 antibody Mast cell chymase 1 antibody Mast cell protease 3 antibody Mast cell protease 5 antibody Mast cell protease I antibody Mast cell protease III antibody Mcp-5 antibody MCP3P antibody Mcpt5 antibody MCT1 antibody MGC119890 antibody MGC119891 antibody MMCP-5 antibody |
| Product description | Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Mast Cell Chymase, also known as CMA1 or MCT1, is a major secreted serine protease that is involved in vasoactive peptide generation, extracellular matrix degradation and regulation of gland secretion. The human chymase gene, which maps to human chromosome 14q11.2, encodes a preproenzyme with a 19 amino acid signal peptide, an acidic 2 amino acid propeptide and a 226 amino acid catalytic domain. Mast Cell Chymase is a chymotryptic serine proteinase which is a member of the peptidase family S1. Expressed in mast cells, Mast Cell Chymase is associated with the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. Mast cell proteases are a family of rodent protein homologs to human tryptases that are specifically expressed in mast cells and may serve as highly specific markers in the analysis of mast cell heterogeneity, differentiation and function. Mast Cell Protease 1, also designated Mcp-1 or Mcpt1, is a rodent specific beta-chymase. The mouse and rat Mast Cell Protease 1 proteins share 76% sequence identity at the amino acid level. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:50-1:200 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | Alpha-chymase antibody
Chymase 1 antibody
Chymase 1 mast cell antibody
chymase 1 preproprotein transcript E antibody
chymase 1 preproprotein transcript I antibody
Chymase antibody
Chymase heart antibody Chymase mast cell antibody CMA1 antibody CMA1_HUMAN antibody CYH antibody CYM antibody EC 3.4.21.39 antibody Mast cell chymase 1 antibody Mast cell protease 3 antibody Mast cell protease 5 antibody Mast cell protease I antibody Mast cell protease III antibody Mcp-5 antibody MCP3P antibody Mcpt5 antibody MCT1 antibody MGC119890 antibody MGC119891 antibody MMCP-5 antibody |
|---|---|
| Molecular Weight(MW) | 27kDa |
| Cellular Localization | Secreted. |
| SwissProt ID | P23946 |
|---|
Application
Fig1: Western blot analysis of Mast Cell Chymase on rat spleen and mouse spleen tissue lysates using anti-Mast Cell Chymase antibody at 1/500 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human skin tissue using anti- Mast Cell Chymase antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti- Mast Cell Chymase antibody. Counter stained with hematoxylin.| Positive Control | Rat spleen and mouse spleen tissue lysates, Human tonsil tissue, human skin tissue. |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
