Application
Fig1: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Cubilin antibody. Counter stained with hematoxylin.| Product Name | Cubilin [JB42-13] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 460 kDa receptor antibody cubilin (intrinsic factor-cobalamin receptor) antibody Cubilin antibody Cubilin precursor antibody Cubn antibody CUBN_HUMAN antibody IFCR antibody Intestinal intrinsic factor receptor antibody intrinsic factor B12-receptor antibody Intrinsic factor-cobalamin receptor antibody Intrinsic factor-vitamin B12 receptor antibody megaloblastic anemia 1 antibody MGA1 antibody |
| Product description | Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:500 IHC:1:50-1:200 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | 460 kDa receptor antibody cubilin (intrinsic factor-cobalamin receptor) antibody Cubilin antibody Cubilin precursor antibody Cubn antibody CUBN_HUMAN antibody IFCR antibody Intestinal intrinsic factor receptor antibody intrinsic factor B12-receptor antibody Intrinsic factor-cobalamin receptor antibody Intrinsic factor-vitamin B12 receptor antibody megaloblastic anemia 1 antibody MGA1 antibody |
|---|---|
| Molecular Weight(MW) | 399 kDa |
| Cellular Localization | Membrane. |
| SwissProt ID | O60494 |
|---|
Application
Fig1: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Cubilin antibody. Counter stained with hematoxylin.| Positive Control | Human kidney tissue. |
|---|---|
| Application Notes | WB:1:500 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
