Application
Fig1: Western blot analysis of SUV39H2 on SiHa cell (1) and A549 cell (2) lysate using anti- SUV39H2 antibody at 1/1,000 dilution.Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti- SUV39H2 antibody. Counter stained with hematoxylin.| Product Name | SUV39H2 [JG36-55] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FLJ23414 antibody H3 K9 HMTase 2 antibody H3-K9-HMTase 2 antibody Histone H3 K9 methyltransferase 2 antibody Histone H3-K9 methyltransferase 2 antibody Histone lysine N methyltransferase H3 lysine 9 specific 2 antibody Histone lysine N methyltransferase SUV39H2 antibody Histone-lysine N-methyltransferase SUV39H2 antibody KMT1B antibody Lysine N methyltransferase 1B antibody Lysine N-methyltransferase 1B antibody sSuppressor of variegation 3 9 homolog 2 (Drosophila) antibody Su(var)3 9 Drosophila homolog of 2 antibody Su(var)3 9 homolog 2 antibody Su(var)3-9 homolog 2 antibody Suppressor of variegation 3 9 homolog 2 antibody Suppressor of variegation 3-9 homolog 2 antibody Suv39h2 antibody SUV92_HUMAN antibody |
| Product description | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. |
| Immunogen | Synthetic peptide within Human SUV39H2 aa 350 to the C-terminus. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHCIP |
| WB:1:500-1:2,000 IHC:1:50-1:200 IP:1:10-1:50 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | FLJ23414 antibody H3 K9 HMTase 2 antibody H3-K9-HMTase 2 antibody Histone H3 K9 methyltransferase 2 antibody Histone H3-K9 methyltransferase 2 antibody Histone lysine N methyltransferase H3 lysine 9 specific 2 antibody Histone lysine N methyltransferase SUV39H2 antibody Histone-lysine N-methyltransferase SUV39H2 antibody KMT1B antibody Lysine N methyltransferase 1B antibody Lysine N-methyltransferase 1B antibody sSuppressor of variegation 3 9 homolog 2 (Drosophila) antibody Su(var)3 9 Drosophila homolog of 2 antibody Su(var)3 9 homolog 2 antibody Su(var)3-9 homolog 2 antibody Suppressor of variegation 3 9 homolog 2 antibody Suppressor of variegation 3-9 homolog 2 antibody Suv39h2 antibody SUV92_HUMAN antibody |
|---|---|
| Molecular Weight(MW) | 40/47 kDa |
| Cellular Localization | Nucleus. |
Application
Fig1: Western blot analysis of SUV39H2 on SiHa cell (1) and A549 cell (2) lysate using anti- SUV39H2 antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti- SUV39H2 antibody. Counter stained with hematoxylin.| Positive Control | SiHa, A549, mouse testis tissue. |
|---|---|
| Application Notes | WB:1:500-1:2,000 IHC:1:50-1:200 IP:1:10-1:50 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
