Application
Fig1: Western blot analysis of Nudel on rat brain tissue lysate using anti-Nudel antibody at 1/2,000 dilution.Application
Fig2: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Nudel antibody. Counter stained with hematoxylin.Application
Fig3: Immunohistochemical analysis of paraffin-embedded human small intestine tissue using anti-Nudel antibody. Counter stained with hematoxylin.Application
Fig4: Immunohistochemical analysis of paraffin-embedded human uterus tissue using anti-Nudel antibody. Counter stained with hematoxylin.| Product Name | Nudel [JG38-63] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | A. nidulans antibody DKFZp451M0318 antibody ENDOOLIGOPEPTIDASE A antibody EOPA antibody MITAP 1 antibody MITAP1 antibody Mitosin associated protein 1 antibody Mitosin associated protein MITAP1 antibody Mitosin-associated protein 1 antibody Ndel 1 antibody NDEL1 antibody NDEL1_HUMAN antibody Nuclear distribution gene E like homolog 1 antibody Nuclear distribution protein nudE like 1 antibody Nuclear distribution protein nudE-like 1 antibody NUDE like protein antibody NudE nuclear distribution gene E homolog like 1 A. nidulans antibody NudE nuclear distribution gene E homolog like 1 antibody NUDEL antibody Protein Nudel antibody |
| Product description | NudE-like protein (Ndel1) is expressed in the testis, brain, heart, hypothalamus, liver, lung, spleen, and stomach, specifically in the interphase centrosome and mitotic spindle. It positively regulates minus-end directed dynein. Evidence suggests that Ndel1 interacts with LIS1 to sustain the function of dynein, thereby impacting microtubule organization, nuclear translocation, and neuronal positioning. Ndel1 is phosphorylated during mitosis and seems to tether dynactin and dynein to the mother centriole for microtubule anchoring. Loss of function of Ndel1 in the developing neocortex impairs neuronal positioning and uncouples the centrosome and nucleus. Ndel1 may also impair mitochondrial transport or function, initiating a cascade of events culminating in psychiatric illness such as lissencephaly and schizophrenia. |
| Immunogen | Recombinant protein corresponding to the N-terminus of human Nudel. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2,000 IHC:1:50-1:200 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | A. nidulans antibody DKFZp451M0318 antibody ENDOOLIGOPEPTIDASE A antibody EOPA antibody MITAP 1 antibody MITAP1 antibody Mitosin associated protein 1 antibody Mitosin associated protein MITAP1 antibody Mitosin-associated protein 1 antibody Ndel 1 antibody NDEL1 antibody NDEL1_HUMAN antibody Nuclear distribution gene E like homolog 1 antibody Nuclear distribution protein nudE like 1 antibody Nuclear distribution protein nudE-like 1 antibody NUDE like protein antibody NudE nuclear distribution gene E homolog like 1 A. nidulans antibody NudE nuclear distribution gene E homolog like 1 antibody NUDEL antibody Protein Nudel antibody |
|---|---|
| Molecular Weight(MW) | 38 kDa |
| Cellular Localization | Cytoskeleton. |
Application
Fig1: Western blot analysis of Nudel on rat brain tissue lysate using anti-Nudel antibody at 1/2,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Nudel antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human small intestine tissue using anti-Nudel antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human uterus tissue using anti-Nudel antibody. Counter stained with hematoxylin.| Positive Control | Rat brain tissue lysate, human liver cancer tissue, human small intestine tissue, human uterus tissue. |
|---|---|
| Application Notes | WB:1:500-1:2,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
