| Product Name | CARD8 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Apoptotic protein NDPP 1 Apoptotic protein NDPP1 CARD 8 CARD inhibitor of NF kappa B activating ligand CARD inhibitor of NF kappaB activating ligand CARD inhibitor of NF kappaB activating ligands CARD-inhibitor of NF-kappa-B-activating ligand CARD8 CARD8_HUMAN CARDINAL Caspase recruitment domain containing protein 8 Caspase recruitment domain family member 8 Caspase recruitment domain protein 8 Caspase recruitment domain-containing protein 8 DACAR NDPP 1 NDPP1 TUCAN Tumor up regulated CARD containing antagonist of CASP9 Tumor up regulated CARD containing antagonist of caspase 9 Tumor up-regulated CARD-containing antagonist of CASP9 Tumor upregulated CARD containing antagonist of CASP9. |
| Product description | Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases. [SUBUNIT] May form homodimers. Interacts with NEMO and DRAL. Binds to caspase-1, CARD16/pseudo-ICE and CARD18/ICEBERG. Interacts with FNBP3 (By similarity). Interacts with NALP2 NACHT domain. |
| Immunogen | KLH conjugated synthetic peptide derived from human CARD8 221-320/431 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-2000: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | Apoptotic protein NDPP 1 Apoptotic protein NDPP1 CARD 8 CARD inhibitor of NF kappa B activating ligand CARD inhibitor of NF kappaB activating ligand CARD inhibitor of NF kappaB activating ligands CARD-inhibitor of NF-kappa-B-activating ligand CARD8 CARD8_HUMAN CARDINAL Caspase recruitment domain containing protein 8 Caspase recruitment domain family member 8 Caspase recruitment domain protein 8 Caspase recruitment domain-containing protein 8 DACAR NDPP 1 NDPP1 TUCAN Tumor up regulated CARD containing antagonist of CASP9 Tumor up regulated CARD containing antagonist of caspase 9 Tumor up-regulated CARD-containing antagonist of CASP9 Tumor upregulated CARD containing antagonist of CASP9. |
|---|---|
| Molecular Weight(MW) | 49 KDa |
| Cellular Localization | Cytoplasm. Nucleus. |
| SwissProt ID | Q9Y2G2 |
|---|
| Positive Control | High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow. |
|---|---|
| Application Notes | WB:1:500-2000: |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
