Application
Fig1: Sample: U-87MG(Human) Cell Lysate at 30 ug Primary: Anti-CCBR1 (ER1905-55) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 55 kD Observed band size: 55 kD| Product Name | CCBR1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Amino acid transport system xc xCT antibody Amino acid transport system xc- antibody Calcium channel blocker resistance protein CCBR1 Calcium channel blocker resistance protein CCBR1 antibody CCBR1 Cysteine/glutamate transporter antibody cystine/glutamate transporter SLC7A11 Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 solute carrier family 7 Solute carrier family 7 member 11 Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 xCT XCT_HUMAN. |
| Product description | This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. |
| Immunogen | KLH conjugated synthetic peptide derived from human xCT/CCBR1 201-300/501 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-2000: |
|
| Species Reactivity | HumanMouseRatDogPigCowHorseSheep |
| Concentration | 1mg/ml |
| Alternative Names | Amino acid transport system xc xCT antibody
Amino acid transport system xc- antibody Calcium channel blocker resistance protein CCBR1
Calcium channel blocker resistance protein CCBR1 antibody CCBR1 Cysteine/glutamate transporter antibody cystine/glutamate transporter SLC7A11 Solute carrier family 7 (anionic amino acid transporter light chain xc- system) member 11 solute carrier family 7 Solute carrier family 7 member 11 Solute carrier family 7 (cationic amino acid transporter y+ system) member 11 xCT XCT_HUMAN. |
|---|---|
| Molecular Weight(MW) | 55 KDa |
| Cellular Localization | Membrane; Multi-pass membrane protein. |
| SwissProt ID | Q9UPY5 |
|---|
Application
Fig1: Sample: U-87MG(Human) Cell Lysate at 30 ug Primary: Anti-CCBR1 (ER1905-55) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 55 kD Observed band size: 55 kD| Positive Control | U-87MG Cell Lysate. |
|---|---|
| Application Notes | WB:1:500-2000: |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
