| Product Name | CHMP1A |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CHMP1A Charged multivesicular body protein 1a Chromatin modifying protein 1a hVps46 1 Metalloprotease 1 PCOLN3 Procollagen (type III) N endopeptidase PRSM1 Vacuolar protein sorting 46 1 Vps46 1 CHM1A_HUMAN. |
| Product description | Probable peripherally associated component of theendosomal sorting required for transport complex III (ESCRT-III)which is involved in multivesicular bodies (MVBs) formation andsorting of endosomal cargo proteins into MVBs. MVBs containintraluminal vesicles (ILVs) that are generated by invagination andscission from the limiting membrane of the endosome and mostly aredelivered to lysosomes enabling degradation of membrane proteins,such as stimulated growth factor receptors, lysosomal enzymes andlipids. The MVB pathway appears to require the sequential functionof ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostlydissociate from the invaginating membrane before the ILV isreleased. The ESCRT machinery also functions in topologicallyequivalent membrane fission events, such as the terminal stages ofcytokinesis and the budding of enveloped viruses (HIV-1 and otherlentiviruses). ESCRT-III proteins are believed to mediate thenecessary vesicle extrusion and/or membrane fission activities,possibly in conjunction with the AAA ATPase VPS4. Involved incytokinesis. Involved in recruiting VPS4A and/or VPS4B to themidbody of dividing cells. May also be involved in chromosomecondensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4to regions of condensed chromatin. May play a role in stable cellcycle progression and in PcG gene silencing. |
| Immunogen | KLH conjugated synthetic peptide derived from human CHMP1A 51-150/196 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRatChickenDogPigCowHorseRabbit |
| Concentration | 1mg/ml |
| Alternative Names | CHMP1A Charged multivesicular body protein 1a Chromatin modifying protein 1a hVps46 1 Metalloprotease 1 PCOLN3 Procollagen (type III) N endopeptidase PRSM1 Vacuolar protein sorting 46 1 Vps46 1 CHM1A_HUMAN. |
|---|---|
| Molecular Weight(MW) | 22 KDa |
| Cellular Localization | Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix. |
| SwissProt ID | Q9HD42 |
|---|
| Positive Control | Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG63. |
|---|---|
| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
