Application
Fig1: Protein: Raji lysate; Primary: rabbit Anti-COMP (ER1906-53) at 1:300; Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000; Predicted band size: 83 kD Observed band size: 77 kD| Product Name | COMP |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Cartilage oligomeric matrix protein Cartilage oligomeric matrix protein precursor EDM 1 EDM1 EPD 1 EPD1 Epiphyseal dysplasia 1 Epiphyseal dysplasia 1 multiple Epiphyseal dysplasia multiple 1 MED MGC13181 MGC149768 PSACH Pseudoachondroplasia THBS 5 THBS5 Thrombospondin 5 Thrombospondin5. |
| Product description | May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7. |
| Immunogen | KLH conjugated synthetic peptide derived from human COMP 221-320/757 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-2000: |
|
| Species Reactivity | HumanMouseRatDogPigCowHorseSheep |
| Concentration | 1mg/ml |
| Alternative Names | Cartilage oligomeric matrix protein Cartilage oligomeric matrix protein precursor EDM 1 EDM1 EPD 1 EPD1 Epiphyseal dysplasia 1 Epiphyseal dysplasia 1 multiple Epiphyseal dysplasia multiple 1 MED MGC13181 MGC149768 PSACH Pseudoachondroplasia THBS 5 THBS5 Thrombospondin 5 Thrombospondin5. |
|---|---|
| Molecular Weight(MW) | 83 KDa |
| Cellular Localization | Secreted, extracellular space, extracellular matrix. |
| SwissProt ID | P49747 |
|---|
Application
Fig1: Protein: Raji lysate; Primary: rabbit Anti-COMP (ER1906-53) at 1:300; Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000; Predicted band size: 83 kD Observed band size: 77 kD| Positive Control | Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect. |
|---|---|
| Application Notes | WB:1:500-2000: |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
