| Product Name | Dmrta1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DMO DMRT-like family A1 Dmrt4 DMRTA_HUMAN Dmrta1 Doublesex- and mab-3-related transcription factor 4 Doublesex- and mab-3-related transcription factor A1. |
| Product description | Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity). |
| Immunogen | KLH conjugated synthetic peptide derived from human Dmrta1 51-100/373 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-2000: |
|
| Species Reactivity | HumanMouseRatDogHorseSheep |
| Concentration | 1mg/ml |
| Alternative Names | DMO DMRT-like family A1 Dmrt4 DMRTA_HUMAN Dmrta1 Doublesex- and mab-3-related transcription factor 4 Doublesex- and mab-3-related transcription factor A1. |
|---|---|
| Molecular Weight(MW) | 41(h)/53(m) KDa |
| Cellular Localization | Nucleus. |
| SwissProt ID | Q5VZB9 |
|---|
| Positive Control | Testis-specific. |
|---|---|
| Application Notes | WB:1:500-2000: |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
