Application
Fig1: Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti-DR6 (ER1907-79) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52/68 kD Observed band size: 52 kDApplication
Fig2: Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti-DR6 (ER1907-79) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52/68 kD Observed band size: 52 kD| Product Name | DR6 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TNFRSF 21 BM 018 BM018 CD358 Death receptor 6 DR 6 MGC31965 TNFR related death receptor 6 TNFRSF21 TNFRSF21 protein TNR21_HUMAN Tumor necrosis factor receptor superfamily member 21 Tumor necrosis factor receptor superfamily member 21 precursor. |
| Product description | May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). |
| Immunogen | KLH conjugated synthetic peptide derived from human DR6/CD358 101-200/655 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-2000: |
|
| Species Reactivity | HumanMouseRatChickenDogCowHorseRabbit |
| Concentration | 1mg/ml |
| Alternative Names | TNFRSF 21 BM 018 BM018 CD358 Death receptor 6 DR 6 MGC31965 TNFR related death receptor 6 TNFRSF21 TNFRSF21 protein TNR21_HUMAN Tumor necrosis factor receptor superfamily member 21 Tumor necrosis factor receptor superfamily member 21 precursor. |
|---|---|
| Molecular Weight(MW) | 52/68 KDa |
| Cellular Localization | Membrane; Single-pass type I membrane protein (Probable). |
| SwissProt ID | O75509 |
|---|
Application
Fig1: Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti-DR6 (ER1907-79) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52/68 kD Observed band size: 52 kD
Application
Fig2: Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti-DR6 (ER1907-79) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52/68 kD Observed band size: 52 kD| Positive Control | Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. |
|---|---|
| Application Notes | WB:1:500-2000: |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
