Application
Fig1: Sample: Hela(Human) Cell Lysate at 30 ug Primary: Anti-FAIM3 (ER1908-53) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41 kD Observed band size: 31 kD| Product Name | FAIM3 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Faim3 FAIM3_HUMAN Fas apoptotic inhibitory molecule 3 Fc mu receptor FCMR IgM Fc receptor Immunoglobulin mu Fc receptor Regulator of Fas induced apoptosis Regulator of Fas-induced apoptosis Toso TOSO. |
| Product description | May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. |
| Immunogen | KLH conjugated synthetic peptide derived from human FAIM3 51-150/390 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-2000: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | Faim3 FAIM3_HUMAN Fas apoptotic inhibitory molecule 3 Fc mu receptor FCMR IgM Fc receptor Immunoglobulin mu Fc receptor Regulator of Fas induced apoptosis Regulator of Fas-induced apoptosis Toso TOSO. |
|---|---|
| Molecular Weight(MW) | 41 KDa |
| Cellular Localization | Isoform 1: Membrane; Single-pass membrane protein. ;Isoform 3: Secreted. Note=Detected in the serum. |
| SwissProt ID | O60667 |
|---|
Application
Fig1: Sample: Hela(Human) Cell Lysate at 30 ug Primary: Anti-FAIM3 (ER1908-53) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 41 kD Observed band size: 31 kD| Positive Control | Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells. |
|---|---|
| Application Notes | WB:1:500-2000: |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
