Application
Fig1: Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti-LXR alpha + LXR beta (ER1912-55) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 51 kD Observed band size: 51 kD| Product Name | LXR alpha + LXR beta |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Liver X receptor alpha Liver X receptor alpha Liver X receptor beta LXR a LXR LXR b LXRa LXRalpha LXRb LXRbeta NER NERI NR1H2 NR1H3 Nuclear orphan receptor LXR alpha Nuclear orphan receptor LXR beta Nuclear receptor NER Nuclear receptor subfamily 1 group H member 2 Nuclear receptor subfamily 1 group H member 3 Oxysterols receptor LXR alpha Oxysterols receptor LXR beta RIP15 RLD1 Ubiquitously expressed nuclear receptor UNR. |
| Product description | Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. |
| Immunogen | KLH conjugated synthetic peptide derived from human LXR alpha + LXR beta 51-150/447 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-2000: |
|
| Species Reactivity | HumanMouseRatChickenDogPigCowHorseRabbitXenopus |
| Concentration | 1mg/ml |
| Alternative Names | Liver X receptor alpha
Liver X receptor alpha
Liver X receptor beta LXR a LXR LXR b LXRa LXRalpha LXRb LXRbeta NER NERI NR1H2 NR1H3 Nuclear orphan receptor LXR alpha Nuclear orphan receptor LXR beta Nuclear receptor NER Nuclear receptor subfamily 1 group H member 2 Nuclear receptor subfamily 1 group H member 3 Oxysterols receptor LXR alpha Oxysterols receptor LXR beta RIP15 RLD1 Ubiquitously expressed nuclear receptor UNR. |
|---|---|
| Molecular Weight(MW) | 51 KDa |
| Cellular Localization | Nuclear |
| SwissProt ID | P55055 |
|---|
Application
Fig1: Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti-LXR alpha + LXR beta (ER1912-55) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 51 kD Observed band size: 51 kD| Positive Control | Heart (Mouse) Lysate. |
|---|---|
| Application Notes | WB:1:500-2000: |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
