| Product Name | RanBP3 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Ran BP-3 Ran binding protein 3 Ran-binding protein 3 RANB3_HUMAN RanBP3. |
| Product description | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. |
| Immunogen | KLH conjugated synthetic peptide derived from human RanBP3 441-540/567 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-2000: |
|
| Species Reactivity | HumanMouseRatChickenDogPig |
| Concentration | 1mg/ml |
| Alternative Names | Ran BP-3 Ran binding protein 3 Ran-binding protein 3 RANB3_HUMAN RanBP3. |
|---|---|
| Molecular Weight(MW) | 60 KDa |
| Cellular Localization | Cytoplasm. Nucleus. |
| SwissProt ID | Q9H6Z4 |
|---|
| Positive Control | Widely expressed with high levels in testis and heart. |
|---|---|
| Application Notes | WB:1:500-2000: |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
