| Product Name | RNF6 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | E3 ubiquitin-protein ligase RNF6 Ring finger protein (C3H2C3 type) 6 Ring finger protein 6 RING H2 protein RING H2 protein RNF6 RNF 6 RNF6 RNF6_HUMAN SPG2. |
| Product description | E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. |
| Immunogen | KLH conjugated synthetic peptide derived from human RNF6 551-650/685 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-2000: |
|
| Species Reactivity | HumanMouseRatChickenDogCowHorseSheep |
| Concentration | 1mg/ml |
| Alternative Names | E3 ubiquitin-protein ligase RNF6 Ring finger protein (C3H2C3 type) 6 Ring finger protein 6 RING H2 protein RING H2 protein RNF6 RNF 6 RNF6 RNF6_HUMAN SPG2. |
|---|---|
| Molecular Weight(MW) | 78 KDa |
| Cellular Localization | Nucleus. Cytoplasm. Cell projection, axon. Nucleus, PML body. Note=Localizes to the PML nuclear bodies in Sertoli cells. |
| SwissProt ID | Q9Y252 |
|---|
| Positive Control | Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues. |
|---|---|
| Application Notes | WB:1:500-2000: |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
