Application
Fig1: Western blot analysis of ROCK1 on different cell lysates using anti-ROCK1 antibody at 1/1000 dilution. Positive control: Lane 1: NIH/3T3 Lane 2: Jurkat Lane 3: HelaApplication
Fig2: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-ROCK1 antibody. Counter stained with hematoxylin.| Product Name | ROCK1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | coiled-coil-containing protein kinase 1 antibody coiled-coil-containing protein kinase I antibody MGC131603 antibody MGC43611 antibody p160 Rhoassociated coiled coil-forming protein kinase antibody p160 ROCK-1 antibody p160 ROCK1 antibody p160ROCK antibody PRO0435 antibody Renal carcinoma antigen NY REN 35 antibody Renal carcinoma antigen NY-REN-35 antibody Rho associated coiled coil containing protein kinase 1 antibody Rho associated protein kinase 1 antibody Rho kinase antibody Rho-alpha kinase antibody Rho-associated antibody Rho-associated protein kinase 1 antibody ROCK I antibody ROCK-I antibody ROCK1 antibody ROCK1_HUMAN antibody Rok antibody rokalpha antibody |
| Product description | ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. ROCK1 has a ubiquitous tissue distribution, but subcellularly it is thought to colocalize with the centrosomes. This is consistent with its function as a key modulator of cell motility, tumor cell invasion, and actin cytoskeleton organization. ROCK1 has a diverse range of functions in the body. It is a key regulator of actin-myosin contraction, stability, and cell polarity. These contribute to many progresses such as regulation of morphology, gene transcription, proliferation, differentiation, apoptosis and oncogenic transformation. Other functions involve smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility. These functions are activated by phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. |
| Immunogen | peptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:1,000 IHC:1:200 ICC:1:200 FC:1:100-1:200 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | coiled-coil-containing protein kinase 1 antibody coiled-coil-containing protein kinase I antibody MGC131603 antibody MGC43611 antibody p160 Rhoassociated coiled coil-forming protein kinase antibody p160 ROCK-1 antibody p160 ROCK1 antibody p160ROCK antibody PRO0435 antibody Renal carcinoma antigen NY REN 35 antibody Renal carcinoma antigen NY-REN-35 antibody Rho associated coiled coil containing protein kinase 1 antibody Rho associated protein kinase 1 antibody Rho kinase antibody Rho-alpha kinase antibody Rho-associated antibody Rho-associated protein kinase 1 antibody ROCK I antibody ROCK-I antibody ROCK1 antibody ROCK1_HUMAN antibody Rok antibody rokalpha antibody |
|---|---|
| Molecular Weight(MW) | 158 kDa |
| Cellular Localization | Cytoplasm, cell membrane, Nucleus |
| SwissProt ID | Q13464 |
|---|
Application
Fig1: Western blot analysis of ROCK1 on different cell lysates using anti-ROCK1 antibody at 1/1000 dilution. Positive control: Lane 1: NIH/3T3 Lane 2: Jurkat Lane 3: Hela
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-ROCK1 antibody. Counter stained with hematoxylin.| Positive Control | Hela, NIH/3T3, Jurkat, human colon cancer tissue |
|---|---|
| Application Notes | WB:1:1,000 IHC:1:200 ICC:1:200 FC:1:100-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
