| Product Name | Cleaved-Caspase-6 p18 (D162) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CASP6 antibody; MCH2 antibody; Caspase-6 antibody; CASP-6 antibody; Apoptotic protease Mch-2 antibody; |
| Product description | CASP6 encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 6 is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of CASP6 results in multiple transcript variants that encode different isoforms. |
| Immunogen | The antiserum was produced against synthesized peptide derived from mouse Caspase 6. AA range:144-193 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | MouseRat |
| Concentration | 1mg/ml |
| Alternative Names | CASP6 antibody MCH2 antibody Caspase-6 antibody CASP-6 antibody Apoptotic protease Mch-2 antibody |
|---|---|
| Molecular Weight(MW) | 28/35 kDa |
| Cellular Localization | Cytoplasm |
| SwissProt ID | O08738 |
|---|
| Positive Control | Highly expressed in lung, liver, kidney, testis, and heart. Lower levels in spleen, skeletal muscle and brain. |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
