| Product Name | Cleaved-Caspase-9 (D353) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CASP9 antibody; MCH6 antibody; Caspase-9 antibody; CASP-9 antibody; Apoptotic protease Mch-6 antibody; Apoptotic protease-activating factor 3 antibody; APAF-3 antibody; ICE-like apoptotic protease 6 antibody; ICE-LAP6 antibody; |
| Product description | CASP9 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 9 can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. Caspase 9 is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Caspase 9. AA range:323-372 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IFWBIHC |
| IF:1:50-200 WB IHC:1:100-1:300 |
|
| Species Reactivity | MouseRat |
| Concentration | 1mg/ml |
| Alternative Names | CASP9 antibody MCH6 antibody Caspase-9 antibody CASP-9 antibody Apoptotic protease Mch-6 antibody Apoptotic protease-activating factor 3 antibody APAF-3 antibody ICE-like apoptotic protease 6 antibody ICE-LAP6 antibody |
|---|---|
| Molecular Weight(MW) | 17 kDa |
| Cellular Localization | Cytosol, Mitochondrion, Nucleus. |
| SwissProt ID | Q8C3Q9 |
|---|
| Application Notes | IF:1:50-200 WB IHC:1:100-1:300 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
