| Product Name | Cleaved-Caspase-4/5 p20 (D270/D311) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CASP4 antibody; ICH2 antibody; Caspase-4 antibody; CASP-4 antibody; ICE(rel)-II antibody; Protease ICH-2 antibody; Protease TX antibody; CASP5 antibody; ICH3 antibody; Caspase-5 antibody; CASP-5 antibody; ICE(rel)-III antibody; Protease ICH-3 antibody; Protease TY antibody; |
| Product description | This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Caspase 4/5. AA range:221-270 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-1:2000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | CASP4 antibody ICH2 antibody Caspase-4 antibody CASP-4 antibody ICE(rel)-II antibody Protease ICH-2 antibody Protease TX antibody CASP5 antibody ICH3 antibody Caspase-5 antibody CASP-5 antibody ICE(rel)-III antibody Protease ICH-3 antibody Protease TY antibody |
|---|---|
| Molecular Weight(MW) | 47/22 kDa |
| Cellular Localization | Cytosol |
| Positive Control | Placenta,Testis,Thymus,Uterus, |
|---|---|
| Application Notes | WB:1:500-1:2000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
