| Product Name | Cleaved-Cathepsin C HC (R394) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CTSC antibody; CPPI antibody; Dipeptidyl peptidase 1 antibody; Cathepsin C antibody; Cathepsin J antibody; Dipeptidyl peptidase I antibody; DPP-I antibody; DPPI antibody; Dipeptidyl transferase antibody; |
| Product description | This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Dipeptidyl-peptidase 1. AA range:345-394 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-1:2000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | CTSC antibody CPPI antibody Dipeptidyl peptidase 1 antibody Cathepsin C antibody Cathepsin J antibody Dipeptidyl peptidase I antibody DPP-I antibody DPPI antibody Dipeptidyl transferase antibody |
|---|---|
| Molecular Weight(MW) | 27 kDa |
| Cellular Localization | Lysosome |
| SwissProt ID | P53634 |
|---|
| Positive Control | Blood,Cerebellum,Human fetal kidney,Ileum,Liver,Pancreas,PCR rescued clones,Rheumatoid arth |
|---|---|
| Application Notes | WB:1:500-1:2000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
