| Product Name | Cleaved-Factor B Bb (K260) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CFB antibody; BF antibody; BFD antibody; Complement factor B antibody; C3/C5 convertase antibody; Glycine-rich beta glycoprotein antibody; GBG antibody; PBF2 antibody; Properdin factor B antibody; |
| Product description | This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complemen |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CFAB Bb. AA range:241-290 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-1:2000 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | CFB antibody BF antibody BFD antibody Complement factor B antibody C3/C5 convertase antibody Glycine-rich beta glycoprotein antibody GBG antibody PBF2 antibody Properdin factor B antibody |
|---|---|
| Molecular Weight(MW) | 57/85 kDa |
| Cellular Localization | Secreted |
| SwissProt ID | P00751 |
|---|
| Positive Control | Blood,Colon,Liver,Plasma, |
|---|---|
| Application Notes | WB:1:500-1:2000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
