| Product Name | SIK1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | catalytic activity:ATP + a protein = ADP + a phosphoprotein. cofactor:Magnesium. enzyme regulation:Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3. PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. Contains 1 protein kinase domain. Contains 1 UBA domain. subcellular location:Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ. subunit:Binds to and is activated by YWHAZ when phosphorylated on Thr-182. |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 130-210 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-1:2000 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Molecular Weight(MW) | 86 kDa |
|---|
| SwissProt ID | P57059 |
|---|
| Positive Control | Fetal lung,Spleen,Testis, |
|---|---|
| Application Notes | WB:1:500-1:2000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
